Neuroprotective potential of incretinomimetics
نویسندگان
چکیده
In the prescriptions of an endocrinologist to patients with diabetes mellitus, glucagon-like peptide agonists, belonging group that affects incretin system body, have recently been increasingly appearing. addition pronounced hypoglycemic effect and high safety, these drugs also many pleiotropic properties due presence receptors in vascular endothelium, kidneys, heart nervous tissue. The purpose this work is describe most studied neuroprotective effects class drugs. As materials course work, studies domestic foreign colleagues published period from 2008 2022 were used. Our has shown GLP-1 associated activation corresponding receptor systems central system, which leads increased cellular survival ischemic conditions by reducing reactive oxygen species, stimulating beta-oxidation mitochondria, pro-inflammatory cytokines. addition, analysis literature established positive role neurodegenerative diseases – reduce amount unnormal proteins (alphasynuclein, microtubular T-peptide, etc.), activity non-enzymatic glycation hyperglycemia, as well insulin resistance. described above analyzed during preclinical trials GLP-1, demonstrated their validity human models some clinical trials. However, data obtained not yet sufficient form clear indications for neurology, so topic requires further study large
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ژورنال
عنوان ژورنال: ??????????? ?????
سال: 2023
ISSN: ['0235-1188', '2618-8961']
DOI: https://doi.org/10.21518/ms2023-159